Prevotella and Gardnerella Are Associated With Treatment Failure Following First-line Antibiotics for Bacterial Vaginosis

EL Plummer; AM Sfameni; LA Vodstrcil; JA Danielewski; GL Murray; G Fehler; CK Fairley; SM Garland; EPF Chow; JS Hocking; CS Bradshaw

Journal article

Prevotella and Gardnerella Are Associated With Treatment Failure Following First-line Antibiotics for Bacterial Vaginosis

EL Plummer, AM Sfameni, LA Vodstrcil, JA Danielewski, GL Murray, G Fehler, CK Fairley, SM Garland, EPF Chow, JS Hocking, CS Bradshaw

Journal of Infectious Diseases | Published : 2023

DOI: 10.1093/infdis/jiad261

Abstract

Background: Bacterial vaginosis (BV) is a common vaginal dysbiosis that often recurs following first-line antibiotics. We investigated if vaginal microbiota composition was associated with BV recurrence. Methods: We analyzed samples and data from 121 women who participated in 3 published trials evaluating novel interventions for improving BV cure, including concurrent antibiotic treatment of regular sexual partners (RSPs). Women diagnosed with BV received first-line antibiotics and self-collected vaginal swabs pretreatment and the day after finishing antibiotics (immediately posttreatment). 16S rRNA gene sequencing was performed on vaginal samples. Logistic regression explored associations b..

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University of Melbourne Researchers

Erica Plummer Author

Lenka Vodstrcil Author

Gerald Murray Author

Suzanne Wark Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The original trials were supported by grants from Central Clinical School, Monash University (Near Miss) and Alfred Health (Alfred Research Trusts Seeding Grant) awarded to C. S. B., L. A. V., C. K. F., and S. M. G. SToPBV was additionally supported by an Early Career Researcher grant from the University of Melbourne to L. A. V. This work was also supported by the Australian National Health and Medical Research Council (NHMRC) (program grant number 1071269 awarded to C. K. F. and S. M. G.). C. S. B., C. K. F., and S. M. G. are supported by the NHMRC (Leadership Investigator grant numbers 1173361, 1172900, and 1197951, respectively) and E. P. F. C. by an NHMRC Emerging Leadership Investigator grant (grant number 1172873). J. S. H. is supported by a NHMRC Senior Research Fellowship (award number 1136117). Funding to pay the Open Access publication charges for this article was provided by Monash University.